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Image Search Results
Journal: Investigational New Drugs
Article Title: Structure-based design, synthesis, and evaluation of the biological activity of novel phosphoroorganic small molecule IAP antagonists
doi: 10.1007/s10637-020-00923-4
Figure Lengend Snippet: The interaction network between the N -terminal tetrapeptide (Ala-Val-Pro-Ile) of Smac and the XIAP BIR3 domain (based on the NMR data) ( a ) and representation of the peptide-binding groove of the BIR3 domain containing the bound N-terminal AVPI motif of Smac (based on 1G73.pdb) ( b )
Article Snippet: Phosphate buffer (pH 7.5) supplemented with γ-globulin (100 µg/mL) and NaN 3 (0.02% w/v ), fluorescent probe 4 and the
Techniques: Binding Assay
Journal: Investigational New Drugs
Article Title: Structure-based design, synthesis, and evaluation of the biological activity of novel phosphoroorganic small molecule IAP antagonists
doi: 10.1007/s10637-020-00923-4
Figure Lengend Snippet: Determination of the binding affinity of fluorescent probe 4 and the XIAP BIR3 domain. The assay was performed at a constant fluorescent probe concentration (2 nM) and serially diluted XIAP BIR3 domain (ranging from 2.5 µM to 0.0763 nM)
Article Snippet: Phosphate buffer (pH 7.5) supplemented with γ-globulin (100 µg/mL) and NaN 3 (0.02% w/v ), fluorescent probe 4 and the
Techniques: Binding Assay, Concentration Assay